In systemic lupus erythematosus, type 4 renal tubular acidosis is often occurred by diffuse immune-comlex deposit in the intersititial tissue and juxtaglomerular apparatus.
A 25-year-old male patient with complaint of generalized eddema, easy fatigability, aopeia and arthralgia for 1 months, he was diagnosed as systemic lupous erythematosus and diffuse proliferative lupus nephritis through the serologic, immunologic
test
and renal biopsy. Simultaneously hyperkalemia, hyperchloremia, metabolic acidosis with normal anion gap was detected but his renal funciton was degected but his renal function was normal. With the bicarbonate loading test and basal and stimulated
plasma
renin, aldosterone level, he was diagnosed as type 4 renal tubular acidosis caused by hyporeninemic hypoaldosteronism.
We repoort this as type 4 renal tubular acidosis associated with systemic lupus erythematosus with review of literature.
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